Team
The consortium is comprised of 18 leading organizations from 5 different countries with a vast background and expertise in the technologies to be developed and implemented:
Genomic and clinical data generation
Ethical and legal issues regarding genomic and clinical data sharing
Data Management
Genomic and clinical data analysis and pipeline benchmarking
HPC and Cloud infrastructure
BARCELONA SUPERCOMPUTING CENTER
Responsibilities:
- Project Coordination
- Development of the EUCANCan platform
- Management of the financial control regarding the European partners
DEUTSCHES KREBSFORSCHUNGS- ZENTRUM HEIDELBERG
Responsibilities:
- Contribution to pipeline development and virtualization
- Contribution to benchmarking of pipelines
- Development of tools for annotation of somatic variants
- Contribution to the Heidelberg ICGC data portal
ONTARIO INSTITUTE FOR CANCER RESEARCH
Responsibilities:
- Develop software for storing, indexing and querying genomic data collected by each EUCANCan node
- Develop a high-speed file transfer service for efficient exchange of clinical and genomic data files among EUCANCan nodes, accessible to authorized users
- Develop software to extract and uniformly annotate genomic variants identified by EUCANCan nodes
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Responsibilities:
- Exploration and testing of cloud infrastructures
- Contribution to the implementation of the pipelines for production environment
- Contribution to the non-clinical omics data integration
- Contribution to the project overall coordination and dissemination
HARTWIG MEDICAL FOUNDATION
Responsibilities:
- Optimization and standardization comprehensive somatic variant calling pipelines
- Improvement of WGS-based therapeutic decision tools and reporting
- Facilitation of connection between the HMF metastatic cancer WGS resource to other resources for research
FUNDACIO CENTRE DE REGULACIO GENOMICA
Responsibilities:
- To define a circuit for long-term raw data and metadata storage and flow, as well as access protocols
- To prepare global infrastructures and facilitate deployment of local infrastructures for the long-term storage and flow of raw data
- To synchronize connectivity and interoperability protocols to interact within EUCANCan system at the level of genomic variant and clinical and phenotypical information
- To adapt these infrastructures to local and national needs in healthcare systems
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Responsibilities:
- Deploy, refine and develop automated tools and annotation to filter and prioritise both germline and somatic alterations to support decision making in tumour boards
- Contribution to pipeline development including for cloud pipelines
CONSORCI INSTITUT D’INVESTIGACIONS BIOMPEDIQUES AUGUST PI I SUNYER
Responsibilities:
- Providing, sharing and screening of the ICGC data of Chronic lymphocytic leukaemia
- Contribution to the integration of clinical and genomic data
- Definition of the oncology essential data set for patient management decisions
INSTITUT CATALÀ D’ONCOLOGIA
Responsibilities:
- Production of samples, mainly Colorectal (advanced and metastatic)
- Contribution to the identification of the best suited oncology minimal data set
- Adaptation and calibration tasks on local site
FUNDACIÓ PROVADA INSTITUT D’INVESTIGACIÓ ONCOLÒGICA VALL D’HEBRON
Responsibilities:
- Identifying the best suited oncology minimal data set of clinical and pathological variables
- Applying genomics interface developed in the consortium to our local molecular prescreening program
- Define a standardised summary report of genomic variants for therapeutic decision
- Develop a trial locator with molecular markers
UNIVERSITÄTSKLINIKUM HEIDELBERG
Responsibilities:
- Contribution to development of central platform
- Contribution to clinical and genomic standards
- Contribution to oncological tools
CHARITE – UNIVERSITÄTSMEDIZIN BERLIN
Responsibilities:
- Contribution to the Berlin ICGC data portal
- Contribution to clinical and genomic standards
- Contribution to oncological tools
INSTITUT CURIE
Responsibilities:
- Develop genome analysis pipelines to support the therapeutic decision
- Implementation of the pipelines for production environment EUCANCan node
THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
Responsibilities:
- Ethico-legal analysis of data sharing and protection issues related to Canada’s participation in EUCANCan
- Develop overarching guidance aimed at all EUCANCan member projects
UNIVERSIDAD DEL PAÍS VASCO/EUSKAL HERRIKO UNIBERTSITATEA
Responsibilities:
- Develop a policy framework to enable international transfer of personal data in the framework of the project, in accordance with European and Canadian Law and regulations
- Provide tools for harmonized legal compliance as a prototype for future research efforts to address common diseases
HEIDELBERGER AKADEMIE DER WISSENSCHAFTEN
Responsibilities:
- Development of the Legal Framework for International Clinical Oncology Data Sharing
- Lead activities which aim to provide ethico-legal policy analysis of data protection issues related to
- EUCANCan member projects in Spain, Germany and other relevant EU member states
- Development of tools usable for harmonized legal compliance in research collaborations into other common diseases
- Development of overarching guidance aimed at all EUCANCan member projects
LINQ MANAGEMENT GMBH
Responsibilities:
- Creating a clear communication framework
- The dissemination and exploitation of the project results
STEINBEIS TRANSFER GMBH
Responsibilities:
- Planning and establishment of working groups in the context of industry and health policy
- Linking the project with international activities in the field of standarization
- Support in planning of the commercial exploitation of the results