WP3 aimed at harmonizing and unifying in silico analysis protocols (including variant identification and functional interpretation) across EUCANCan nodes, to allow the posterior exchange and integration of the results of the different studies generated, setting up a common technical environment for genome analysis that allows and promotes the sharing of data. Deliverables from this WP include compute facilities, open to EUCANCan and ARGO participants, which implement standard alignment, variant-calling, and genome annotation pipelines.